Sixth St. was named because it is the 6th street from the Fox River. It has become somewhat of a main thoroughfare since it continues Badger St. from the west and leads to the Oneida St. bridge which continues south across the Fox River.
The street was a landmark back to the earliest time of Appleton since it bordered the County Courthouse on the south.
From Morrow and Gillett's Appleton city directory, for 1889-90:
SIXTH, 462 Cherry [now S. Memorial Dr.], east to Prospect, fourth south of College av, numbers from 890 to 1040
In 1925 a new system of numbering structures in the city of Appleton was adopted. In this directory both the new and old street numbers are given. In addition, College Ave. was designated the dividing line between north and south, and Oneida St. was the east-west divider.
From Wright's Appleton city directory 1925:
SIXTH W - From 321 W Prospect av w to S Cherry [now S. Memorial Dr.], 4 s W College av